We at Novus Biologicals have a large antibody catalog covering apoptosis research. The Bcl-2 antibody is one of a number of products suitable for Early Apoptotic Marker studies.
Apoptosis has a number of triggers: heat, radiation, chemical damage and hypoxia being just some of them. It is regulated by a complex series of extracellular and intracellular pathways, involving proteins which may either induce or suppress apoptosis. Initiation of programmed cell death does not always result in destruction of the cell.
Since the 1990s, research has identified a large number of apoptotic marker proteins, which can be found in our apoptosis antibody catalogue. These include a growing number of early apoptosis markers, including Caspase 3, Bax, p53, Annexin-V, SMAC/Diablo and Bcl-2 antibody products.
EAMs provide researchers with valuable information about early biochemical and morphological changes. Annexin-V, for example, is widely used as an Early Apoptotic Marker owing to its binding affinity for phosphatidilserine, a compound which travels from the cytosolic side of the membrane to the membrane surface, at an early stage of apoptosis.
Apoptosis is regulated by several pathways, the main two being the mitochondrial regulation pathway, and the direct signal transduction pathway.
SMAC (small mitochondria-derived activator of caspase) proteins are important mitochondrial markers, which bind to and deactivate IAPs (inhibitor of apoptosis proteins). A mitochondrial apoptosis-induced channel (MAC) then forms, triggering release of Cytochrome c from the mitochondria. This triggers apoptotic events on the caspase cascade, and cleavage of caspase-3.
Bcl-2 antibody research has identified the MAC pore to be regulated by several marker proteins of the Bcl-2 family, all of which can be found in our antibody catalog.
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